ARTICLE
Heritability of biochemical and anthropometric parameter markers of cardiovascular risk:
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Heritability of biochemical and anthropometric parameter markers of cardiovascular risk:
a study with twins
Michelle Vasconcelos de Oliveira Borges 1,4 , Elys Costa de Sousa 4 , Luciano Alonso 2 , Leidjaira Juvanhol Lopes 3 ,
Radamés Maciel Vítor Medeiros 4 , Telma Maria Araújo Moura Lemos 5 , Paulo Moreira Silva Dantas 1,4
1 Department of Physical Education, Health Sciences Center, Federal University of Rio Grande do Norte (UFRN),
Natal, Brazil,
2 School of Physical Education and Sports, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil,
3 Department of Nutrition and Health, Federal University of Viçosa, Viçosa, Brazil,
4 Laboratory of the movement, Federal University of Rio Grande do Norte (UFRN), Natal, Brazil,
5 Department of Clinical and Toxicological Analysis, Health Sciences Center, Federal University of Rio Grande do Norte (UFRN), Natal, Brazil
Radamés Maciel Vítor Medeiros 4 , Telma Maria Araújo Moura Lemos 5 , Paulo Moreira Silva Dantas 1,4
1 Department of Physical Education, Health Sciences Center, Federal University of Rio Grande do Norte (UFRN),
Natal, Brazil,
2 School of Physical Education and Sports, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil,
3 Department of Nutrition and Health, Federal University of Viçosa, Viçosa, Brazil,
4 Laboratory of the movement, Federal University of Rio Grande do Norte (UFRN), Natal, Brazil,
5 Department of Clinical and Toxicological Analysis, Health Sciences Center, Federal University of Rio Grande do Norte (UFRN), Natal, Brazil
Abstract
The present study has the objective of investigating the heritability of anthropometric and biochemical markers as predictors of cardiovascular risk in a sample with children, adolescents, and adults from the Northeast of Brazil, considering the scarcity of studies with this population, using the method of twins.
Material and Method. The sample was composed of 88 twins, 52 children and adolescents and 36 adults. Stature, body mass, waist circumference, BMI, fasting glycemia, total cholesterol, HDL-C, LDL-C, and triglycerides were analyzed. Heritability analysis of the biochemical and anthropometric indicators was performed by means of structural equation modeling in the Mplus program, version 7.4. This analytical approach typically decomposes the phenotypic variance into three components: genetic (A), common or shared environmental (C), and non-shared environmental (E) - ACE model.
Results. When testing the ACE model, the presented biochemical and anthropometric parameters did not demonstrate significant inherited components. The best adjustment for all these parameters was CE, indicating that the shared and non-shared components were stronger.
Conclusion. By identifying the heritability of these parameters, it becomes possible to carry out specific intervention strategy planning. A lifestyle with practice of regular physical exercise and healthy habits may be able to modify the action of inherited components, responsible for the predisposition to obesity and cardiovascular risk.
Key words:
twins, obesity, genetic inheritance, anthropometry, lipid profile, cardiovascular risk
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