ARTICLE –
abstractComparative
effects of different concentrations of sorbitan monooleate on
electromotive administration of diclofenac diethylamine in subjects
with knee osteoarthritis Onigbinde Ayodele Teslim1, Ogunye Oluwaseyi Martins1, Bamitale Kayode DS2, Adetoogun Gbadegesin Elubode3, Ojoawo AO1, Kambalametore SVK4, Margaret Wazakili4, M’kumbuzi Vyvienne4 1Medical
Rehabilitation Department, Faculty of Basic Medical Sciences, Obafemi
Awolowo University, Ile-ife, Osun State, Nigeria 2Department
of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences,
Obafemi Awolowo University, Ile-ife, Osun State, Nigeria 3Department of Pharmaceutics, Faculty of Pharmacy, Obafemi Awolowo University, Ile-ife, Osun State, Nigeria 4Department of Physiotherapy, College of Medicine, University of Malawi, Blantyre, Malawi, Nigeria
Abstract
Aim and
scope. The purpose of this study was to determine the effects of 2
different concentrations of sorbitan monooleate and methylated spirit
as surfactants in the electromotive administration of diclofenac
diethylamine among participants with knee osteoarthritis (OA). Materials
and methods: Fifteen participants with knee OA were randomly allocated
into 3 groups. Prior to diclofenac diethylamine iontophoresis,
participants in group 1 had the stimulation electrode pads soaked in 1%
w/v sorbitan monooleate and same procedures were adopted for those in
group 2 and 3 but soaking and cleansing were in 0.5% w/v sorbitan
monooleate and methylated spirit surfactants respectively. The data
were analyzed using descriptive and inferential statistics. Results.
There was significant reduction in pain intensity immediately after the
first treatment session within group 1, (p< 0.02) and group 3,
(p<0.05) but there was no significant difference in pain intensities
of the subjects who received 0.5% sorbitan monooleate (group 2). Also,
there was significant increase in knee flexion of group 1 participants
after the first treatment session (p< 0.006). At 4th week, there was
no significant difference in pain intensity and active knee flexion
ROMs across the groups. Conclusion. The study concluded that there
was no difference in the cumulative effects of 1%, 0.5%w/v sorbitan
monooleate concentrations and methylated spirit as surfactants at the
end of 4 weeks. However, 1% w/v of sorbitan monooleate concentration
and methylated spirit enhanced reduction in pain intensity and increase
in knee flexion at first treatment session.
Key
words:diclofenac, sorbitan monooleate, iontophoresis, osteoarthritis
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