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"Medicina Sportiva" No.14 - 2008 The 15-th Sports Medicine Balkan Congress
APPLIED EXERCISE PHYSIOLOGY


EXPRESION OF CALCITONIN RECEPTOR IN THE RAT TEMPORO – MANDIBULAR JOINT STRUCTURES

Eleftherios G. Kaklamanos 1,2, Theodora Papamitsou 1, Louise Economou 1, Antonia Sioga 1,
1Department of Histology & Embryology, Medical School, Aristotle University of Thessaloniki, Thessaloniki,
2Department of Orthodontics, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece

INTRODUCTION. Calcitonin is a natural peptide hormone produced by parafollicular cells (C-cells) in the thyroid gland. Binding of low concentrations of calcitonin to the calcitonin receptor on osteoclasts induces a rapid change in the cytoskeletal structure of the osteoclasts in vitro, which in turn leads to a reduction in bone resorption. Furthermore, calcitonin has been recently shown to possess regulatory actions on cartilage and subchondral bone, which may cause long-term clinical benefits. The aim of this study is to investigate the expression and localization of calcitonin receptor in the rat temporomandibular joint structures.
MATERIALS/METHODS. Forty-eight 21-day-old male Wistar rats were housed in well-ventilated stainless cages with 12-hour light-dark cycle and a maximum of 3 rats per cage. The rats were provided food and water ad libitum. Six animals were sacrificed every time at days 3, 7, 10, 14, 17, 21, 24, 28. The right temporomandibular joints were dissected, fixed (10% neutral formalin for 24 h), demineralised (10 days in 5% formic acid), embedded in paraffin (4-μm thick sections) and processed for immunohistochemical staining of the calcitonin receptors. The protocols were approved by the appropriate University committee.
RESULTS. Immunoexpression of calcitonin receptors was evident intensively around the bony cavities and mildly in some muscle fibers.
CONCLUSIONS. Calcitonin receptors are expressed in the bony and muscle structures of the rat temporomandibular joint. The physiologic importance of calcitonin receptor expression for the development of the region remains to be clarified.
KEY WORDS: calcitonin, calcitonin receptor, rat, temporomandibular joint.





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