Gene
therapy and
musculoskeletal diseases
Vasilescu
Mirela1, Rusu Ligia1,
Ionescu Anca2,
Dragomir M1
1University
of Craiova
2UMF
Carol Davila Bucharest
Abstract
Gene
therapy represents the transfer of
a gene or a fragment
of the gene into a somatic cell to produce a therapeutic effect. The
transfer of genetic material in the interior of the cell can be
realized on multiple ways, the most often used being the viral
vector. For this, the virus is subjected to a genetic engineering
with the purpose of modifying its infectious potential, keeping its
capacity to transport one or more genes inside a target cell.
If
the initial gene transfer has targeted only a therapeutic purpose, as
the treating of genetic diseases, cancer, infections and degenerative
diseases, in present we can observer an amplification of the usage
sphere also in the sports world, both as a therapeutic mean in the
specific traumatic pathology, but also for the sport performance
enhancement, as a way of doping.
Taking
in consideration the subject of the musculoskeletal affections
treatment at athletes through gene therapy the authors make a short
introduction of some results from the specialty literature of the
last years referring to the research conducted in this direction.
Key
words:
gene, musculoskeletal tissues.