ARTICLE –
abstractAnabolic
androgenic steroids and doping in sport Filomena Mazzeo, Antonio Ascione Department
of Institutional and Territorial Systems Studies, University
Parthenope, Naples, Italy
Abstract
Anabolic
steroids, technically known as anabolic-androgenic steroids (AAS), are
synthetic derivatives of testosterone, modified to enhance its anabolic
actions (promotion of protein synthesis and muscle growth). They are
used by athletes (weightlifters, shot, hammer, discus or javelin
throwers, rugby and American football players, swimmers and runners) to
increase muscular mass and athletic performance and by bodybuilders to
improve size and cosmetic appearance. AAS were the first identified
doping agents that have ergogenic effects and are on the International
Olympic Committee’s list of banned substances. The most
popular AS used as doping substances are: oximetolone,
oxandrolone, testosterone undecanoate, nandrolone decanoate, nandrolone
undercanoate, methandrostenolone. To reach high dosages and
rapid effects, steroid users practice a method known as “staking” which
consist in the intake of two or more steroids in high dosages. Another
method, called “pyramiding” provides a progressive increase of steroids
dosage. The pyramid protocol is alternated with drug-free, process
defined as “cycle”. AAS abuse causes significant side effect:
infertility, azoospermia, testicular atrophy, and gynecomastia in men
and in women may develop excessive body hair growth, menstrual
irregularity, hypertrophy of sebaceous glands, acne. Other side effects
are: premature cease of growth caused by premature epiphysis closure;
Alteration of cardiovascular function; increase of platelet aggregation
and plasmatic levels of low density lipoproteins (LDL); liver damage;
euphoria, aggressiveness and psychosis. Their action in central neuron
system involves the dopaminergic neurotransmission and produces
amphetamine-like activity. Therefore, the use of AAS should be banned
from the sport, making a work of supervision and accountability of the
sports centers and authorities in this field.
Key
words:anabolic
androgenic steroid; doping; endocrinology; testosterone.
Full
article:
Anabolic androgenic steroids and doping in sport
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