of kinetotherapy for improvement of the osteo-articular
in patients with secreting GH pituitary tumors
Elena R. Ionescu1,
Mihaela N. Popescu1, Elena Taina Avramescu2,
University of Medicine and Pharmacy, Craiova,Romania
University of Craiova, Romania
The purpose of the study is to appreciate the incidence, clinical
and paraclinical characteristics of the pituitary tumors
secreting growth hormone (GH) in Dolj county and to evaluate the impact
of a kinetotherapy programme on the osteo-articular pathology
associated to acromegaly.
hereby study was performed in the Craiova Emergency County Hospital,
having a retrospectiv component and a prospectiv one, by direct
supervision, for a two – year period (2008-2010).
We choose a group of 19 patients, divided in 3 subgroups. All patients
folowed specific medication for the basic disease. Suplimentary to this
treatment, study group I followed a medication based on calcium and D
vitamin, associated with kinetotherapy; for group II therapy
included calcium and D vitamin, specific antiresorbitiv medication and
kinetotherapy; group III (witness) received complete
medication like group II, but without physical
therapy. We evaluated bone density by osteodensitometry –
DEXA, bone makers – serum osteocalcin. The evaluation of the
lumbar spine pain was realised after an analogous visual scale (SVA).
Evaluations were carried on before begining the treatment and after 6
months of treatment and physical controlled activity.
This study showed the clear favorable evolution of the scores of pain
at the patients from the groups I and II, more emphasized
than for group III. Analysis of bone density showed the best results
for group II (improvment of scores), no decreases of scores for group I
and slight decrease for group III. As regarding the bone markers at the
end of the 6 months of kinetotherapy it was noticed that the values
went down in all cases, at the group I being registrated the decrease
of the marker statistically semnificative (p < 0,05) while at
the patients from group II the decrease was not statistically
exercise ameliorates the pain and can modify the bone turnover in the
sense of balancing the resorbtion – formation processes.
tumors, bone density, serum osteocalcin, kinetotherapy