levels and physical activity in patients with coronary artery disease
Roxana Buzas, Constantin Tudor, Rodica Mihaescu
of Medicine and Pharmacy „V.Babes”, Timisoara,
and scope. Hyperhomocysteinemia (Hcy) is emerging as an
independent atherosclerosis risk factor. Physical activity has been
associated with lower homocysteine levels in some population studies,
especially among elderly subjects. Our aim is to further elucidate the
observed association between homocysteine and physical activity in a
group of patients with coronary artery disease (CAD).
We included a group of 90 patients with CAD: 58 (64.44%) men and 32
women (35.55%) with a median age of 62±5 years. We
divided our group in 3 according to the answer gave to the question
,,Do you engage in any intentional physical
activity?’’ The first group (A) included patients
who’s answer was no. The other two groups included patients
with weekly physical activity of more than 3.5 hours (B), respectively
with less than 3,5 hours (C). Fasting plasma Hcy levels were determined
from venous blood using automated chemiluminescence immunoassay.
The Hcy values for the total sample ranged from 2.6 to
22.1 μmol/l; the arithmetic-mean plasma level was
11.2±5.4 μmol/l. Hcy levels were higher in males
12.2±5.9 μmol/l compared to females
10.1±4.4 μmol/l; p<0.001. Among the sedentary
population (group A), median Hcy levels were significantly higher
compared to the physically active participants (group C), a finding
which persisted when controlling for sex (11.7 μmol/l
vs 10.9 μmol/l for males and 9.7 μmol/l
vs 9.1 μmol/l for females, respectively; p=0.01). Conclusions.
We propose physical activity as an alternative approach to reduce Hcy
levels without the potential of adversely affecting the development of
the atherogenic plaque. Physical activity is an important component of
secondary prevention at patients with CAD.
artery disease, homocysteine, physical activity