of body mass index and gender upon liver stiffness values in patients
with chronic hepatitis B and nonreplicative B virus carriers versus
Diana Nicoliţă1, Ioan
Sporea1, Corina Vernic2
of Gastroenterology and Hepatology, University of Medicine and Pharmacy
“Victor Babes” Timişoara, Romania
of Medical Informatics and Biostatistics, University of Medicine and
Pharmacy “Victor Babes” Timişoara, Romania
To assess how gender and body mass index might influence liver
stiffness measurements in patients with chronic hepatitis B,
nonreplicative B virus carriers compared to healthy subjects as well as
studying the effects of sedentary behavior upon liver stiffness (LS).
and method: We performed an observational study on healthy subjects,
nonreplicative B virus carriers and chronic hepatitis B patients from
the Department of Gastroenterology, Timisoara. Patients were subdivided
according to physical behavior. LS measurements were obtained by using
FibroScan (Echosens, France). Body mass index (BMI) was calculated for
every subject. Mean value for LS was calculated for each group.
We evaluated 152 healthy subjects (87 women, 65 men, mean age
43.5±15.9), 139 nonreplicative B virus carriers (71 women,
men, mean age 38.6±12.9) and 352 patients diagnosed with
hepatitis B (116 women, 236 men, mean age 41.9±14.3). Among
three groups, 319 subjects affirmatively underwent moderate program of
physical activity and 324 subjects had sedentary life. Male gender had
significant higher LS values compared to female in all 643 subjects:
healthy subjects (p<0.0001), nonreplicative B virus carriers
(p=0.023) and patients with chronic hepatitis B (p=0.025). Patients
with chronic hepatitis B who underwent moderate physical activity had a
mean LS value significantly lower than those who were sedentary
(6.5±2.4 kPa versus 7.2±2.6 kPa,
According to BMI, obese patients from the healthy group had a mean LS
value significantly higher compared to underweight persons
(5.4±1.7kPa vs 3.9±0.7kPa, p=0.023).
Male gender had higher LS values compared to female in all groups of
subjects. Patients who affirmatively underwent moderate physical
activity had lower LS values compared to those who were sedentary.
BMI≥25 kg/m² influences liver stiffness values.
formula to correct liver stiffness value with gender and BMI may
reflect more accurately liver fibrosis.
mass index, physical activity, gender, liver stiffness