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"Medicina Sportiva" No.14 - 2008 The 15-th Sports Medicine Balkan Congress


Danilo Acimovic 1, Jelenka Nikolic 2
1Faculty of Philosophy, Department of Sport and Rehabilitation, University of Novi Pazar,
2Medical Faculty, Department of Biochemistry, University of Nis, Serbia

Introduction. Creatine is being studied as a supplement that may help in many diseases affecting the neuromuscular system. Supplementation of creatine to athletes needs additional investigations about its effect on kidney function. There are reports of renal dysfunction due to creatine supplementation, but there is no information about pre- or existing kidney dysfunction in creatine supplementation. It is known that adverse effects of alcohol on renal function may include glomerular and tubulo-interstitial damage.
Materials/methods. Experimental study of the effect of creatine was performed in healthy and in animals treated with alcohol. In evaluation of kidney function we have measured plasma levels of urea and creatinine, which are still markers of kidney function. Male Sprague Dawley rats were treated for 3 weeks with 1- ethanol (as 15% solution), 2- creatine monohydrate (2g/kg/daily), and 3- ethanol+creatine monohydrate in same doses). 4-control group.
Urea and creatinine in blood plasma were measured by standard biochemical analyses.
Results. of our study show that creatine supplementation increases levels of urea and creatinine in plasma, which is higher in animals treated simulanely with ethanol compared to control group (p<0.001).
Conclusion. Results of our study show that creatine supplementation increases plasma levels of urea and creatinine. Effect of creatine on plasma levels of urea and creatinine is higher in alcohol consumption. Obtained results may be caused by disturbance of kidney function but it is necessarily to exclude other factors, which may contribute to their increase such as the level of their synthesis.
Key words: creatine, urea, creatinine.

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