IN TOP ATHLETES
OF DIETARY CREATINE
SUPPLEMENTATION ON KIDNEY FUNCTION
Jelenka Nikolic 2
of Philosophy, Department of Sport and Rehabilitation, University of
Faculty, Department of Biochemistry, University of Nis, Serbia
Creatine is being studied as a supplement that may help in many
diseases affecting the neuromuscular system. Supplementation of
creatine to athletes needs additional investigations about its effect
on kidney function. There are reports of renal dysfunction due to
creatine supplementation, but there is no information about pre- or
existing kidney dysfunction in creatine supplementation. It is known
that adverse effects of alcohol on renal function may include
glomerular and tubulo-interstitial damage.
Experimental study of the effect of creatine was performed in healthy
and in animals treated with alcohol. In evaluation of kidney function
we have measured plasma levels of urea and creatinine, which are still
markers of kidney function. Male Sprague Dawley rats were treated for 3
weeks with 1- ethanol (as 15% solution), 2- creatine monohydrate
(2g/kg/daily), and 3- ethanol+creatine monohydrate in same doses).
Urea and creatinine in blood plasma were
by standard biochemical analyses.
Results. of our
study show that creatine supplementation increases levels of urea and
creatinine in plasma, which is higher in animals treated simulanely
with ethanol compared to control group (p<0.001).
of our study show that creatine supplementation increases plasma levels
of urea and creatinine. Effect of creatine on plasma levels of urea and
creatinine is higher in alcohol consumption. Obtained results may be
caused by disturbance of kidney function but it is necessarily to
exclude other factors, which may contribute to their increase such as
the level of their synthesis.
Key words: creatine,