NUTRITION
IN TOP ATHLETES
CREATINE SUPPLEMENTATION
INCREASES PROTEIN SYNTHESIS IN CARDIAC MUSCLE
Jelenka
Nikolic, 1 Danilo Acimovic, 2
D Stojanovic 3
1Faculty
of Medicine, University of Nis,
2Faculty
of Philosophy, University of Novi Pazar,
3Public
Health, University of Nis, Serbia
Introduction.
Protein synthesis is essential for muscle growth and development and is
important for muscle recovery. There are some information that creatine
modulates protein synthesis. We have study where creatine may increase
protein synthesis in healthy and in alcohol treated rats. The purpose
of this study was to determine the effect of creatine supplementation
on the level of protein synthesis in the myocardial muscle
Materials/Methods.
Male Sprague Dawley rats were treated for 3 weeks: 1-Control, 2-
treated with Creatine monohydrate (2g/kg/daily, 3- Ethanol (as 15%
solution), and 4- with Ethanol and Creatine in the same doses. After
the treatment we have measured tissue protein level, and arginase
activity in hart tissue homogenate.
Results.
Obtained results show increases synthesis of protein after creatine
supplementation (P<0.02). . Protein synthesis was followed by
increases of arginase activity. Arginase is enzyme of arginine
metabolism. The enzyme catalyzes the cleavage of arginine to urea and
ornithine. Ornithine by the activity of ornithine decarboxylase gives
putrescine, which is a precursor for polyamines, spermidine and
spermine. It is known that polyamines has important role in protein
synthesis.
C
Cre Eth Eth+Cre
| 
C Cre
Eth Eth+Cre
|
Key
words: creatine, arginase, protein synthesis.
|
