serum leptin with physical activity in patients with metabolic syndrome
Andreea Iana1, Timar R.2,
Tudor C3, Elena Sîrbu4
Hospital Municipal, Timisoara,
of Medicine and Pharmacy „V.Babes”, Timisoara
Education and Sport Faculty, West University of Timisoara, Romania
The metabolic syndrome (MetS) is a highly prevalent multifaceted
clinical entity produced through the interaction of genetic, hormonal,
and lifestyle factors. MetS is accompanied by an increased risk of type
2 diabetes and cardiovascular complications. Hyperleptinemia plays an
important role in the formation of MetS. The aim of the study was to
assess the influence of physical activity on leptin serum levels in
patients with MetS.
Methods and materials.
The study enrolled 76 patients with metabolic syndrome, 42 men (55.26%)
and 34 women (44.76%) with the mean age of 50.06 ± 5.7
years. The metabolic syndrome was defined according to the IDF. The
patients were divided in two groups: a group of 54 participants with
sedentary behavior and a group of 22 participants who underwent a six
months program of moderate physical activity. Serum leptin
was measured by using a specific radio-immunoassay kit (SPI BIO).
The mean leptin levels by patients with lake of physical activity was
33.42 ng/mL ± 15.14 and by patients with physical activity
was 19.65 ng/mL ± 17.50 (p ANOVA<0.001). The patients
who underwent the program of physical activity had lower values of
glycemia (112.54 mg/dl ± 21.36) and abdominal waist (108.45
cm ± 9.10) than the sedentary group of participants
(glycemia 117.11 mg/dl ± 26.24 and abdominal waist 118.39 cm
leptin levels were lower in patients with MetS who underwent a moderate
program of physical activity over a six months period of time.
Sedentary behavior was correlated with high serum leptin levels.
Lifestyle changes might show additional effect on the hyperleptinemia
which is a key in the pathogenesis of MetS and its complications.
syndrome, physical activity, serum leptin levels.