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"Medicina Sportiva" No.14 - 2008 The 15-th Sports Medicine Balkan Congress
NUTRITION IN TOP ATHLETES


CREATINE SUPPLEMENTATION INCREASES PROTEIN SYNTHESIS IN CARDIAC MUSCLE

Jelenka Nikolic, 1 Danilo Acimovic, 2 D Stojanovic 3
1Faculty of Medicine, University of Nis,
2Faculty of Philosophy, University of  Novi   Pazar,
3Public Health, University of Nis, Serbia

Introduction. Protein synthesis is essential for muscle growth and development and is important for muscle recovery. There are some information that creatine modulates protein synthesis. We have study where creatine may increase protein synthesis in healthy and in alcohol treated rats. The purpose of this study was to determine the effect of creatine supplementation on the level of protein synthesis in the myocardial muscle
Materials/Methods.  Male Sprague Dawley rats were treated for 3 weeks: 1-Control, 2- treated with Creatine monohydrate (2g/kg/daily, 3- Ethanol (as 15% solution), and 4- with Ethanol and Creatine in the same doses. After the treatment we have measured tissue protein level, and arginase activity in hart tissue homogenate.
Results. Obtained results show increases synthesis of protein after creatine supplementation (P<0.02). . Protein synthesis was followed by increases of arginase activity. Arginase is enzyme of arginine metabolism. The enzyme catalyzes the cleavage of arginine to urea and ornithine. Ornithine by the activity of ornithine decarboxylase gives putrescine, which is a precursor for polyamines, spermidine and spermine. It is known that polyamines has important role in protein synthesis.


C  Cre  Eth  Eth+Cre

C  Cre  Eth  Eth+Cre

Conclusion. Results of our study show beneficial effect of creatine on protein synthesis in the heart muscle. Effect of creatine is probably result of increased arginase activity and production of ornithine for polyamine synthesis. 
Key words: creatine, arginase, protein synthesis.






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