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"Medicina Sportiva" No.14 - 2008 The 15-th Sports Medicine Balkan Congress
APPLIED EXERCISE PHYSIOLOGY


EXPRESION OF CALCITONIN RECEPTOR IN THE RAT QUADRICEPS FEMORIS MUSCLE

Theodora Papamitsou1, Eleftherios G. Kaklamanos 1,2, Alexandros Toskas 1, Christos Papanastasiou 1, Louise Economou 1, Antonia Sioga 1
1Department of Histology & Embryology, Medical School, Aristotle University of Thessaloniki, Thessaloniki,
2Department of Orthodontics, Dental School, Aristotle University of Thessaloniki, Thessaloniki, Greece

INTRODUCTION. Calcitonin is a natural peptide hormone produced by parafollicular cells (C-cells) in the thyroid gland. Binding of low concentrations of calcitonin to the calcitonin receptor on osteoclasts induces a rapid change in the cytoskeletal structure of the osteoclasts in vitro, which in turn leads to a reduction in bone resorption. Furthermore, calcitonin has been recently shown to possess regulatory actions on cartilage and subchondral bone, which may cause long-term clinical benefits. The expression of calcitonin receptors in muscles has not been adequately investigated. The aim of this study is to investigate the expression of calcitonin receptor in the rat quadriceps femoris muscle.
MATERIALS/METHODS. Twelve 21-day-old male Wistar rats were housed in well-ventilated stainless cages with 12-hour light-dark cycle and a maximum of 3 rats per cage. Six of them were provided food and water ad libitum and the rest only water for two days, after which all the animals were sacrificed. The right quadriceps femoris muscles were dissected, fixed (10% neutral formalin for 24 h), embedded in paraffin (4-μm thick sections) and processed for immunohistochemical staining of the calcitonin receptors. The protocols were approved by the appropriate University committee.
RESULTS. Immunoexpression of calcitonin receptors was evident in the connective tissue around the muscle fibers.
CONCLUSIONS. Calcitonin receptors are expressed in the connective tissue around the muscle fibers of the quadriceps femoris muscle. The physiologic importance of calcitonin receptor expression for the development of the region remains to be clarified.
KEY WORDS: calcitonin, calcitonin receptor, rat, quadriceps femoris.





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